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Dianabol is run at 50 mg a day for 6 weeks with testosterone (any ester) about 500 mg per week. In both studies, the researchers found similar effects on the brain."It was clear that testosterone and DHEA were having a greater impact on our neural circuits," said study leader Susanne K. Muhlmann, Ph.D., professor at University of Texas Medical Branch. "We also saw an increase in neurotransmitter release in the striatum — another reward center — during performance on tests of memory, in this case tests that involve remembering to press a lever."Study co-author Daniel M. H. Klein, Ph.D., of Texas Medical Center, said that the findings could hold broad applicability: "If we can figure out how to control for these sex differences, we could potentially slow down aging by reducing testosterone, or we could make the brain more responsive to dopamine" — which can contribute to the benefits of exercise."In addition, we found decreased levels of the stress hormone corticosterone and, interestingly, decreased levels of the stress hormone cortisol during sleep deprivation," said Klein. "DHEA has been noted as a possible antidepressant agent with potential effects on sleep."DHEA has been known to affect the endocannabinoid system, a pathway of molecules that can influence moods by interacting with receptors in the brain."DHEA promotes the formation and maintenance of synapses and synaptogenesis, a process necessary for learning and memory, but is the most abundant neurochemical metabolite in the brain and therefore also the most readily available," says the study (doi: 10.1111/j.1365-2742.2006.00781.x).As part of the review of hormone research, the article's authors said DHEA should "also receive similar attention for stimulating the formation and maintenance of new synapses," adding there is a "possible role for DHEA in the modulation of synaptic plasticity."The review, "Effects of Sex Steroids on the Endocrine Mediators of Learning and Memory in Male and Female Rats," was published July 15 in the journal Frontiers in Physiology 2.About the article:http://www.sciencemag.org/content/340/6314/1217.abstractFollow Science News on Twitter@scienceinsiders. We're also on Facebook&Google+.Similar articles: